Evidence map›Paper›PMID 41659299›Full record

ArticleEJIFCC2026

Evaluation of Urinary Albumin/Creatinine Ratio Strip Assay: A Reliable Screening Alternative to Replacing the Quantitative Biochemical Methods.

Antonio Sierra-Rivera, Manuela María Morales-Garcés, Pedro José Villafruela-Rodríguez-Manzaneque, Judit Méndez-Izquierdo, Diego Carmona-Talavera, Laura Sahuquillo-Frías

Abstract read
In one paragraph

Article in EJIFCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonio Sierra-RiveraDepartment of Clinical Biochemistry, Valencia General University Hospital, Valencia, Spain.ORCID https://orcid.org/0000-0001-7824-7239
Manuela María Morales-GarcésDepartment of Clinical Biochemistry, Valencia General University Hospital, Valencia, Spain.
Pedro José Villafruela-Rodríguez-ManzanequeDepartment of Clinical Biochemistry, Valencia General University Hospital, Valencia, Spain.
Judit Méndez-IzquierdoDepartment of Clinical Biochemistry, Valencia General University Hospital, Valencia, Spain.
Diego Carmona-TalaveraDepartment of Clinical Biochemistry, Valencia General University Hospital, Valencia, Spain.
Laura Sahuquillo-FríasDepartment of Clinical Biochemistry, Valencia General University Hospital, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clinical laboratories play a crucial role in the diagnosis and monitoring of chronic kidney disease. Quantitative measurement of urinary albumin, expressed as the albumin/creatinine ratio (ACR), is the most commonly used biomarker for this purpose. This study evaluates the feasibility of using urinary strips as a screening tool for ACR, compared with conventional biochemical methods. Specifically, we assessed the diagnostic performance of the urinary strip and the potential economic impact of implementing this screening approach. Materials and methods: This study included 1,257 samples obtained in primary care, with systematic assessment of requests for urinary strip tests and biochemical quantification of urinary albumin and creatinine. Semiquantitative measurements were performed using Unamax autoanalyzer and quantitative determinations were conducted using AU5800 autoanalyzer. Diagnostic indicators for ACR were calculated for different albumin and creatinine levels. Economic effects were analyzed based on the costs of both testing methods. Results: Results at different cut-off values for albumin and creatinine showed optimal performance at 10 mg/L and above 100 mg/dL, respectively. 666 biochemical quantification tests (53.85% screening) for urinary albumin and creatinine could have been avoided during the study period, resulting in total savings of 522.81€. Conclusions: The present study supports the use of Unamax autoanalyzer for ACR measurement as a screening tool, avoiding unnecessary quantitative measurement, as well as allowing early identification of patients with pathological albuminuria levels. The economic impact was significant, demonstrating effective optimisation of financial resources and workflow efficiency in clinical laboratories.

Indexed as

albumin/creatinine ratiochronic kidney diseaseurinary strip

Identifiers

PMID41659299
PMCPMC12882088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.