ArticleTranslational lung cancer research2026
Comprehensive genomic profiling of synchronous invasive adenocarcinoma and squamous cell carcinoma within the same lobe: a case report.
Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Synchronous multiple primary lung cancers are rare. The field cancerization model posits that carcinogen exposure leads to molecular damage and epigenetic reprogramming in the bronchial epithelium, predisposing individuals to multiple tumors. However, genetic factors may explain why only some individuals develop synchronous primaries. Whole genome sequencing (WGS) offers comprehensive insights into somatic mutations, structural variants, and DNA repair defects, surpassing the limitations of histology or exome sequencing. Case Description: An 80-year-old male underwent left upper lobectomy. The initial biopsy suggested adenocarcinoma, but the final specimen revealed two distinct invasive carcinomas: a 2.1 cm × 1.9 cm acinar- and papillary-predominant adenocarcinoma and a 1.1 cm × 0.7 cm non-keratinizing squamous cell carcinoma. WGS identified 564 variants across both tumors, with only six shared (Jaccard index 0.022). Tumor mutational burden was moderate (6.04 mutations/Mb in adenocarcinoma; 5.24 in squamous carcinoma). Clonal relatedness metrics, including variant allele frequency and cancer cell fraction correlations, were weak, supporting independent origins. Genomic analysis revealed a truncating Conclusions: This case demonstrates that synchronous lung cancers may result from the combined effects of carcinogen-induced field cancerization and DNA repair deficiencies. The identification of
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