Evidence map›Paper›PMID 41659229›Full record

ArticleSynthetic and systems biotechnology2026

Metabolic engineering and adaptive laboratory evolution enhance squalene production in

Qiao-Qin Zhao, Peng-Cheng Hu, Chuan-Jiang Zhang, Meng-Yao Zhu, Yun Tian, Xiao-Na Yang, Xiao-Jun Ji, Chang-Zhu Li, Xiao-Man Sun, Xiang-Yang Lu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiao-Qin ZhaoCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Peng-Cheng HuCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Chuan-Jiang ZhangCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Meng-Yao ZhuCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Yun TianCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Xiao-Na YangCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Xiao-Jun JiCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Chang-Zhu LiState Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, Hunan, 410004, China.
Xiao-Man SunSchool of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, Jiangsu, 210023, China.
Xiang-Yang LuCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.
Hu-Hu LiuCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Squalene, a multifunctional natural compound with diverse bioactivities, has significant potential in the nutraceutical and health industries. Microbial synthesis using engineered cell factories represents a sustainable alternative to conventional methods of extracting from plants or animals. This study systematically optimized squalene production in

Indexed as

Adaptive laboratory evolutionMetabolic engineeringMevalonate pathwaySqualeneYarrowia lipolytica

Identifiers

PMID41659229
PMCPMC12874323

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.