Evidence map›Paper›PMID 41659208›Full record

ReviewGenes & diseases2026

Recent advances in human papillomavirus vaccines and therapeutic strategies: Combating cervical and non-cervical cancers.

Md Rezaul Islam, Abdur Rauf, Most Nazmin Aktar, Md Naeem Hossain Fakir, Sadiya Islam Trisha, Asraful Islam Asif, Md Harun Or Rashid, Md Ibrahim Khalil Al-Imran, Gazi Kaifeara Thufa, Farhana Prodhan Emu and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Md Rezaul IslamDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Abdur RaufDepartment of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
Most Nazmin AktarSchool of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Md Naeem Hossain FakirDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Sadiya Islam TrishaDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Asraful Islam AsifDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Md Harun Or RashidSchool of Engineering, Macquarie University, Sydney, New South Wales, Australia.
Md Ibrahim Khalil Al-ImranDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Gazi Kaifeara ThufaDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Farhana Prodhan EmuDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Hassan A HemegDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Medinah, Al-Monawara 41477, Saudi Arabia.
Hanan A OgalyChemistry Department, College of Science, King Khalid University, Abha 61421, Saudi Arabia.
Rekha ThiruvengadamCentre for Global Health Research-Helix Research Lab, Department of Neonatology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, Tamil Nadu 602105, India.
Seung-Hyun KimDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, South Korea.
Muthu ThiruvengadamDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomaviruses (HPV) are a major cause of several cancers, particularly cervical cancer, and remain a serious public health challenge, particularly in low-resource countries. In addition to cervical cancer, HPV is linked to vulvar, vaginal, penile, anal, and oropharyngeal cancers, especially in men. The integration of HPV into the human genome plays a key role in cancer development. This review highlights the progress in HPV vaccination and new treatment approaches for non-cervical HPV-related cancers. Current vaccines provide strong protection against cervical cancer, and next-generation vaccines aim to protect against more types of cancer-causing HPV. New immunotherapy strategies, such as DNA-based vaccines and antigen-specific immunotherapy, are being developed to more effectively target HPV-driven cancers. Promising methods, such as CRISPR/Cas9 gene editing, therapeutic vaccines, and immune checkpoint inhibitors, have shown success in early research and clinical trials. Among these, DNA vaccines stand out as cost-effective and scalable solutions for treating HPV-related tumors. This review also explores the biology of HPV-related cancers, global trends, and the latest advances in prevention and treatment. To reduce the burden of HPV-related diseases, a combined approach involving vaccination, early detection, and personalized treatment is essential. Ongoing research on therapeutic vaccines, gene therapies, and immune-based treatments could greatly improve the management of HPV-related cancers, potentially lowering their global impact. Expanding these innovations in clinical practice may significantly reduce the global burden of HPV-related malignancies.

Indexed as

Cervical cancerGene editingHuman papillomavirusImmunotherapyProphylactic vaccinesTherapeutic vaccines

Identifiers

PMID41659208
PMCPMC12874431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.