Evidence map›Paper›PMID 41659114›Full record

ReviewReviews in cardiovascular medicine2026

Current Evidence on the Potential Role of Endothelial

Xinting Zhang, Jiao Yang, Zeyuan Yang, Ting Liu, Bingqian Zeng, Mingxi Ma, Ying Liu, Shuanglan Xu, Xiqian Xing

Abstract readReview
In one paragraph

Review in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinting ZhangDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0006-5285-8588
Jiao YangDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan, China.ORCID https://orcid.org/0000-0002-6202-5022
Zeyuan YangState Key Laboratory of Primate Biomedical Research, 650500 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0006-8029-4046
Ting LiuDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0000-5521-723X
Bingqian ZengDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0002-2911-4389
Mingxi MaDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0008-4129-3854
Ying LiuDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0001-5682-598X
Shuanglan XuDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0000-0002-4333-3804
Xiqian XingDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, 650021 Kunming, Yunnan, China.ORCID https://orcid.org/0000-0002-5359-1778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary hypertension (PH) is characterized by an abnormally high pressure within the pulmonary arteries, which can be attributed to various factors. Severe diseases affecting pulmonary vessels may result in heart failure and potentially lead to death; these conditions are linked to significant mortality and unfavorable outcomes. Approximately 1% of adults worldwide have PH, and this condition may affect up to 10% of people older than 65 years. Currently, the mechanisms involved in the development of PH are not fully known and are thought to result from multiple coordinated factors. This lack of understanding remains a bottleneck in clinical practice. Numerous studies have confirmed that pulmonary artery endothelial cell (PAEC) dysfunction plays an important role in occlusive pulmonary vascular remodeling and the pathogenesis of PH. Src homology region 2 domain-containing phosphatase-1 (

Indexed as

endothelial cellspulmonary hypertensionSHP-1vascular remodelling

Identifiers

PMID41659114
PMCPMC12873671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.