ArticleBrain communications2026
Optic nerve and susceptibility imaging at asymptomatic stage of multiple sclerosis: impact and predictive value.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact.Annals of clinical and translational neurology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optic nerve is now included as a fifth typical location in multiple sclerosis diagnosis criteria. The radiologically isolated syndrome represents the earliest stage of multiple sclerosis. Previous optical coherence tomography studies in this asymptomatic context reported no or slight retinal thickness difference compared to healthy subjects. Frequency of asymptomatic optic nerve lesions has never been evaluated at this stage of the disease. Susceptibility-weighted imaging findings on brain MRI are incorporated in the recent revised multiple sclerosis diagnostic criteria (2024) through the 'central vein sign' and 'paramagnetic rim lesion' parameters but for the diagnosis of asymptomatic form, 'paramagnetic rim lesion' are not included. In this study, we aim to measure the frequency of optic nerve lesions in radiologically isolated syndrome and to evaluate their impact on retinal thicknesses. Second, we aim to evaluate the association of optic nerve lesion and susceptibility-weighted imaging parameters with the disease course. This retrospective cohort study collected data (August 2020 to December 2024) on patients with radiologically isolated syndrome at Lille (France). MRI was performed at baseline and every year. Optic nerves were studied using MRI and optical coherence tomography performed on the same day by measuring retinal thickness intereye difference. Clinical examination was performed every 6 months. We included 32 untreated patients (63 eyes; one eye excluded due to the fortuitous discovery of an ocular melanoma). Nine optic nerves showed lesions on MRI in the orbital or canalicular part. These eyes had a thinner peripapillary retinal nerve fibre layer compared to eyes without optic nerve lesions on MRI (median = 87.4 µm versus 96.8 µm,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.