Evidence map›Paper›PMID 41659024›Full record

ArticleAtherosclerosis plus2026

Prelamin A accumulation overlaps increased vascular calcification in peripheral artery disease and regulates vascular smooth muscle cells mineralization in diabetes mellitus.

Eduardo Varejão Díaz Placencia, Elisângela Farias-Silva, Melissa Regina Fessel, Maria Claudina de Andrade, Luciana Simão Carmo, Cynthia de Almeida Mendes, Nelson Wolosker, Alexandre Leme Godoy Dos Santos, Tulio Diniz Fernandes, Marcel Liberman

Abstract read
In one paragraph

Article in Atherosclerosis plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eduardo Varejão Díaz PlacenciaHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Elisângela Farias-SilvaHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Melissa Regina FesselHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Maria Claudina de AndradeHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Luciana Simão CarmoHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Cynthia de Almeida MendesHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Nelson WoloskerHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Alexandre Leme Godoy Dos SantosHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.
Tulio Diniz FernandesInstituto de Ortopedia e Traumatologia - Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo, Brazil.
Marcel LibermanHospital Israelita Albert Einstein: Sociedade Beneficente Israelita Brasileira Albert Einstein, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the mechanistic intersection between aging, diabetes mellitus (DM), and prelamin A accumulation in vascular calcification (VC) progression in patients with peripheral arterial disease (PAD) undergoing lower limb amputation. Arterial segments were collected from amputated PAD patients with (PAD + DM, n = 10) and without DM (PAD, n = 8), as well as from non-vascular amputated patients (CTRL, n = 3). Additional in vivo and

Indexed as

AgingDiabetes mellitusPrelamin AVascular calcification

Identifiers

PMID41659024
PMCPMC12874100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.