Evidence map›Paper›PMID 41658991›Full record

ArticleJournal of the Endocrine Society2026

Age-specific Contributions to Height in Boys with Klinefelter Syndrome: Analysis of Growth Using the QEPS Model.

Anton Holmgren, Aimon Niklasson, Lars Gelander, Andreas F M Nierop, Aldina Pivodic, Anders Juul, Lise Aksglaede

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anton HolmgrenDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41685 Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-0940-8726
Aimon NiklassonDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41685 Gothenburg, Sweden.
Lars GelanderDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41685 Gothenburg, Sweden.
Andreas F M NieropDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41685 Gothenburg, Sweden.
Aldina PivodicAPNC, Entreprenörsstråket 10, 431 53 Mölndal, Sweden.
Anders JuulDepartment of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-0534-4350
Lise AksglaedeDepartment of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-7885-7467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Increased height is a characteristic of Klinefelter syndrome (KS). Detailed evaluation of growth patterns in boys and adolescents carrying a 47,XXY karyotype is lacking. Objective: To delineate detailed growth patterns during the different growth phases and their contribution to the increased adult height in boys with KS. Methods: Longitudinal data on growth from 55 boys with KS were compared with a reference from the GrowUp Results: The infant growth period was shorter with a lower height gain ( Conclusion: The boys with KS exhibited a different growth pattern as compared with a healthy reference population, with less and shorter growth in infant life and more basic growth during childhood and the pubertal years (the Q-function growth by the QEPS model), resulting in taller adult height.

Indexed as

growth patternsKlinefelter syndromeQEPS growth modelTRT

Identifiers

PMID41658991
PMCPMC12878342

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.