SynthesisFrontiers in bioengineering and biotechnology2026
Clinical stem cell therapy in oral and craniofacial bone regeneration: a systematic review and meta-analysis.
Synthesis in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Craniofacial development: genetics, signaling pathways, teratogenic mechanisms, and clinal significance.Molecular biomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Craniomaxillofacial bone regeneration poses significant clinical challenges due to the anatomical complexity of this region and the inherent limitations of conventional reconstructive techniques. Stem cell-based therapies have emerged as a promising alternative in that stem cells harness the capacities of multilineage differentiation and paracrine signaling to enhance tissue regeneration. Nonetheless, the overall clinical efficacy of stem cell therapy remains a subject of debate. In this systematic review and meta-analysis, we aimed to comprehensively evaluate the safety and effectiveness of stem cell therapy in oral and craniofacial bone regeneration. A comprehensive search of PubMed/MEDLINE, Scopus, Embase, and Web of Science was conducted in July 2024, identifying 59 eligible prospective studies-including randomized controlled trials (RCTs), controlled clinical trials and single-arm studies-involving more than five participants each. Risk of bias was assessed using the Cochrane RoB 2 tool for randomized studies and ROBINS-I for non-randomized studies. The included studies encompassed a broad range of surgical indications, such as alveolar cleft repair, alveolar ridge augmentation, sinus floor augmentation, periodontal defect regeneration, mandibular fracture management, pathological bone defect repair, and temporomandibular joint disorders. Over three-quarters of studies utilized bone marrow aspirate (BMA) and/or mesenchymal stem cells (MSCs), either alone or combined with biomaterial scaffolds. Across diverse procedures, stem cell therapy was associated with clinical and histological benefits, especially in the quality and maturity of regenerated bone. Meta-analysis showed that the addition of stem cells significantly improved the histologic quality of regenerated bone ( Systematic review registration: The protocol of this systematic review was registered on PROSPERO with the ID CRD42024619352.
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