Evidence map›Paper›PMID 41658981›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Venous thromboembolism in patients with breast, ovarian, and uterine cancer. A comparative analysis from the Registro Informatizado Enfermedad TromboEmbólica registry.

Olga Gavín Sebastián, Javier Trujillo-Santos, María Del Carmen Díaz-Pedroche, Pablo Demelo-Rodríguez, Sonia Otálora, Benjamin Brenner, José María Pedrajas, Alessandra Bura-Riviere, Luis Hernández-Blasco, Manuel Monreal and 1 more

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Olga Gavín SebastiánDepartment of Haematology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
Javier Trujillo-SantosDepartment of Internal Medicine, Hospital General Universitario Santa Lucía, Universidad Católica San Antonio de Murcia, Murcia, Spain.
María Del Carmen Díaz-PedrocheDepartment of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
Pablo Demelo-RodríguezDepartment of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Sonia OtáloraDepartment of Internal Medicine, Hospital Universitario Virgen de Arrixaca, Murcia, Spain.
Benjamin BrennerDepartment of Haematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
José María PedrajasDepartment of Internal Medicine, Hospital Clínico San Carlos, Madrid, Spain.
Alessandra Bura-RiviereDepartment of Vascular Medicine, Hôpital de Rangueil, Toulouse, France.
Luis Hernández-BlascoPneumology Department of Clinical Medicine, Miguel Hernandez University, Instituto de Investigación Sanitaria y Biomédica de Alicante, Dr Balmis University General Hospital, Alicante, Spain.
Manuel MonrealFaculty of Health Sciences, Universidad Católica San Antonio de Murcia, Spain, Centro de Investigacion Biomedica en Red Enfermedades Respiratorias (CIBERES), Madrid, Spain.
RIETE investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The risk of recurrent venous thromboembolism (VTE) and bleeding during anticoagulation may vary by the cancer type. Objectives: We assessed outcomes during anticoagulation in women with breast, ovarian, or uterine cancer and VTE. Methods: We analyzed data from the Registro Informatizado Enfermedad TromboEmbólica registry on 4721 women with active breast ( Results: Uterine cancer patients had the highest rates of major bleeding (11.1 per 100 patient-years) and fatal bleeding (1.07 per 100 patient-years), while ovarian cancer patients had the highest rate of VTE recurrences (7.29 per 100 patient-years). In contrast, breast cancer patients had the lowest event rates overall. Among low-molecular-weight heparin-treated patients, major bleeding was higher in uterine (6.37 per 100 patient-years) and ovarian (4.62 per 100 patient-years) cancer than breast cancer patients (1.89 per 100 patient-years). Direct oral anticoagulant use was associated with low recurrence rates in breast cancer (0.58 per 100 patient-years), but outcomes in uterine cancer remained less favorable. Multivariable models confirmed cancer-specific risks. Conclusions: VTE outcomes vary significantly by cancer type. Patients with uterine cancer face an elevated bleeding risk, potentially impacting anticoagulant continuity and contributing to VTE recurrence. These findings support the need for cancer-specific risk assessment and individualized anticoagulation strategies adapted to the specific cancer type.

Indexed as

anticoagulationbreast cancerovarian canceruterine cancervenous thromboembolism

Identifiers

PMID41658981
PMCPMC12874569

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