Evidence map›Paper›PMID 41658976›Full record

ArticleMaterials today. Bio2025

Functionalized hydrocaffeic acid-chitosan/EGTA hydrogel rescues mitochondrial dysfunction for immunomodulation and joint repair in rheumatoid arthritis.

Jianxin Li, Yingchen Ni, Yanjie Tao, Hao Cai, Anqi Wu, Fengyuan Zhang, Shijie Meng, Yuyang Luo, Weidong Zhang, Youhua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianxin LiDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Yingchen NiDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Yanjie TaoDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Hao CaiDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Anqi WuDepartment of Laboratory Medicine, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, 226001, China.
Fengyuan ZhangDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Shijie MengDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Yuyang LuoDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Weidong ZhangDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Youhua WangDepartment of Orthopaedic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by progressive joint degradation, with mitochondrial dysfunction significantly contributing to its pathogenesis. Despite extensive research into therapeutic strategies, successfully addressing mitochondrial dysfunction in RA poses a significant challenge. This paper presents an innovative functionalization method, deploying hydrocaffeic acid-modified chitosan, in conjunction with the selective calcium chelator ethylene glycol bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), and incorporating stromal cell-derived factor 1 alpha (SDF-1α).

Indexed as

Calcium overloadCartilage regenerationCellular senescenceMitochondrial dysfunctionReactive oxygen speciesRheumatoid arthritis

Identifiers

PMID41658976
PMCPMC12879476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.