Evidence map›Paper›PMID 41658732›Full record

ArticleCureus2026

Unilateral Tongue and Lip Edema: A Rare Presentation of Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema.

Gonçalo Carneiro, Iara Ferreira, Catarina Reigota

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gonçalo CarneiroInternal Medicine, Unidade Local de Saúde de Entre Douro e Vouga, Santa Maria da Feira, PRT.
Iara FerreiraInternal Medicine, Unidade Local de Saúde de Entre Douro e Vouga, Santa Maria da Feira, PRT.
Catarina ReigotaInternal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin-converting enzyme (ACE) inhibitor-induced angioedema is a rare but potentially life-threatening adverse effect that may occur years after treatment initiation. Although it typically presents with bilateral facial or oropharyngeal swelling, unilateral tongue involvement is exceptionally rare and diagnostically challenging. We report the case of a 77-year-old man on long-term ACE inhibitor therapy who presented with sudden unilateral tongue and lip edema. Symptoms improved with supportive treatment and drug discontinuation. This case highlights the importance of recognizing atypical presentations to ensure prompt diagnosis, appropriate management, and improved patient safety.

Indexed as

ace inhibitor-inducedbradykinin-mediated angioedemadrug-related side effectstongue angioedemaunilateral angioedema

Identifiers

PMID41658732
PMCPMC12880894

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.