Evidence map›Paper›PMID 41658701›Full record

ArticleCureus2026

Cytomegalovirus Infection-Associated Hemophagocytic Lymphohistiocytosis and Histiocytic Necrotising Lymphadenitis Progressing to Systemic Lupus Erythematosus: A Case Report.

Madhushan Ranabahu, Sachinthana Sumanasekara, Dilini Wickramaratne, Vasana Mendis, Prasanna Weerawansa

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madhushan RanabahuDepartment of Medicine, Postgraduate Institute of Medicine, University of Colombo, Colombo, LKA.
Sachinthana SumanasekaraDepartment of Pathology, University of Peradeniya, Kandy, LKA.
Dilini WickramaratneDepartment of Pathology, Base Hospital - Thambuththegama, Anuradhapura, LKA.
Vasana MendisDepartment of Pathology, Rajarata University of Sri Lanka, Anuradhapura, LKA.
Prasanna WeerawansaDepartment of Medicine, Rajarata University of Sri Lanka, Anuradhapura, LKA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune multisystem disorder predominantly seen in young females. Its clinical presentation is enormously heterogeneous. Genetic, epigenetic and environmental factors cause SLE. Secondary hemophagocytic lymphohistiocytosis (HLH) associated with cytomegalovirus (CMV) infection is observed in immunocompromised patients and is rare in immunocompetent patients. Histiocytic necrotising lymphadenitis (HNL) is a self-limiting hyperimmune reaction rarely associated with HLH. CMV infection can be associated with HLH, HNL, and SLE. In this case, we discuss an immunocompetent young female patient who presented with an upper respiratory tract infection, which led to HLH and HNL associated with CMV infection. She recovered with initial intravenous methylprednisolone pulse immunosuppressive treatment. However, the patient later evolved into SLE.

Indexed as

cytomegalovirushemophagocytic lymphohistiocytosishistiocytic necrotising lymphadenitislupus nephritissystemic lupus erythematosus

Identifiers

PMID41658701
PMCPMC12873442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.