ArticleCureus2026
Second-Degree Atrioventricular Block Following Acute Pregabalin Intoxication: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Pregabalin is widely prescribed for neuropathic pain and anxiety disorders and is generally considered to have a favorable cardiovascular safety profile. However, rare cardiac conduction disturbances have been reported, mainly in overdose settings. We report the case of a 29-year-old woman admitted to the intensive care unit for toxic coma secondary to acute pregabalin intoxication, complicated by a second-degree atrioventricular block with 2:1 conduction. The patient required mechanical ventilation and transient chronotropic support with isoproterenol. Cardiac investigations were unremarkable. The clinical course was rapidly favorable after supportive management and drug discontinuation. This case highlights a rare but potentially serious cardiac adverse effect of pregabalin intoxication and emphasizes the importance of electrocardiographic monitoring.
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