ArticleFrontiers in medicine2026
Age-related changes in circulating immune factors reveal biomarkers of immunosenescence.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immunosenescence, characterized by the decline and restructuring of immune system components with age, affects both innate and adaptive immunity. The predictive value of soluble factors in immunosenescence remains unclear. Objective: To investigate the predictive value of sCD28 (Soluble CD28), sCD40L (CD40 Ligand), sCD25 (Soluble CD25), IL-6 (Interleukin-6) and sPD-1 (Soluble Programmed Cell Death Protein 1) for immunosenescence in a general population, to evaluate their diagnostic potential using ROC curve analysis, including both individual and combined detection efficacy. Methods: We analyzed 131 healthy individuals across four age groups: young (≤44 years, Results: sPD-1, IL-6, and sCD28 levels positively correlated with age ( Conclusion: sPD-1, IL-6, and sCD28 are associated with immunosenescence and have diagnostic potential, with IL-6 showing the highest individual efficacy. Importantly, their combined detection enhances diagnostic accuracy for immunosenescence, highlighting their synergistic predictive value for immune aging.
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