ArticleFrontiers in medicine2026
Relationship between lacrimal gland changes and corneal parameters in patients with primary Sjögren's syndrome and non-Sjögren's syndrome-related dry eye.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
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9 authors.
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Abstract
Background: Primary Sjögren's syndrome(pSS) is characterized as an autoimmune disorder mostly involving exocrine glands and pSS related dry eye (SSDE) contributes to a severe subtype of dry eye disease (DED). Emerging imaging tools for ocular surface evaluation such as lacrimal gland ultrasonography (LGUS) and Methods: This prospective cross-sectional study enrolled 27 SSDE patients and 12 non-pSS related dry eye (NSSDE) controls, utilizing IVCM and LGUS to assess corneal nerve morphology, immune cell activity, and glandular structural parameters. Results: SSDE patients exhibited greater nerve tortuosity ( Conclusion: SSDE patients experience more corneal epithelial injury, with progressive lacrimal gland changes contributing to corneal nerve damage and inflammation. Multimodal ophthalmic imaging elucidates the interconnected lacrimal gland-corneal neuroimmune dysfunction in SSDE, offering potential diagnostic biomarkers and therapeutic targets for future exploration.
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