Evidence map›Paper›PMID 41658562›Full record

ArticleLIPIcs : Leibniz international proceedings in informatics2025

Temporal Ensemble Logic for Integrative Representation of the Entirety of Clinical Trials.

Xiaojin Li, Yan Huang, Rashmie Abeysinghe, Zenan Sun, Hongyu Chen, Pengze Li, Xing He, Shiqiang Tao, Cui Tao, Jiang Bian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in LIPIcs : Leibniz international proceedings in informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojin LiThe University of Texas Health Science Center at Houston, TX, USA.
Yan HuangThe University of Texas Health Science Center at Houston, TX, USA.
Rashmie AbeysingheThe University of Texas Health Science Center at Houston, TX, USA.
Zenan SunThe University of Texas Health Science Center at Houston, TX, USA.
Hongyu ChenUniversity of Florida, Gainesville, FL, USA.
Pengze LiMayo Clinic in Florida, Jacksonville, FL, USA.
Xing HeIndiana University Bloomington, Bloomington, IN, USA.
Shiqiang TaoThe University of Texas Health Science Center at Houston, TX, USA.
Cui TaoMayo Clinic in Florida, Jacksonville, FL, USA.
Jiang BianIndiana University Bloomington, Bloomington, IN, USA.
Licong CuiThe University of Texas Health Science Center at Houston, TX, USA.
Guo-Qiang ZhangThe University of Texas Health Science Center at Houston, TX, USA.

Funding

ACTS (AD Clinical Trial Simulation): Developing Advanced Informatics Approaches for an Alzheimer's Disease Clinical Trial Simulation SystemR01AG084236 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jiang Bian, Cui Tao · 2023 to 2026
$4.1M
NIA NIH HHS R01 AG084236
6 · The paper itself

Abstract

Clinical trials are typically specified with protocols that define eligibility criteria, treatment regimens, follow-up schedules, and outcome assessments. Temporality is a hallmark of all clinical trials, reflected within and across trial components, with complex dependencies unfolding across multiple time points. Despite their importance, clinical trial protocols are described in free-text format, limiting their semantic precision and the ability to support automated reasoning, leverage data across studies and sites, or simulate trial execution under varying assumptions using Real-World Data. This paper introduces a formalized representation of clinical trials using Temporal Ensemble Logic (TEL). TEL incorporates metricized modal operators, such as "always until

Indexed as

Clinical trialsLogic-based modelingTemporal ensemble logicTheory and algorithms for application domainsTheory of computation

Identifiers

PMID41658562
PMCPMC12875094

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.