Evidence map›Paper›PMID 41658431›Full record

ArticleInternational journal of clinical and experimental pathology2026

A seven-gene panel with diagnostic and prognostic value for idiopathic pulmonary fibrosis and candidate herbal drugs identified based on these genes.

Yu Song, Xianglin Meng, Jiaqi Tian, Yunhe Hao, Kai Zeng, Likun Zhang, Jiannan Zhang, Kaili Zhang, Yu Xin, Changsong Wang and 1 more

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Article in International journal of clinical and experimental pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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11 authors.

Yu SongKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Xianglin MengKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Jiaqi TianKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Yunhe HaoKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Kai ZengKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Likun ZhangKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Jiannan ZhangKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Kaili ZhangKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Yu XinKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Changsong WangKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
Kaijiang YuKey Laboratory of Critical Care Medicine of Heilongjiang Province, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to identify key idiopathic pulmonary fibrosis (IPF) related genes, thereby establishing a novel IPF diagnostic/warning panel and proposing drugs against IPF based on the strategy of targeting key genes.

methodsThe GEO datasets GSE245965, GSE279637, and GSE235435 were used to select IPF-related genes, as well as the IPF associated genes from the GeneCards and DisGeNET databases. The DEGs were used for enrichment analysis, PPI network construction, and targeted therapeutic value analysis.

resultsAn intersection analysis yielded 60 commonly up-regulated genes and 16 commonly down-regulated genes. GO/KEGG/Reactome/Immunologic Signature terms that were novel and interesting were found to be enriched. In the interaction network, WDR90 and ANKRD1 were identified as hub genes. Among the 60 common up-regulated genes, seven (namely SERPINB3, TUBB3, SERPINB4, CHTF18, BAX, WDR90 and ITGAX) were shared by the disease sets. In the Symmap database, we found some herbs with the most targets, such as Lygodii Spora, Smilacis Glabrae Rhizoma, and Aloe.

conclusionsA panel comprising seven key IPF genes was identified, which may have diagnostic and prognostic value for IPF. A comprehensive analysis of the Dgidb database revealed potential drugs that may be antitumor agents against IPF, such as Lygodii Spora, Smilacis Glabrae Rhizoma, and Aloe.

Indexed as

bioinformaticsenrichment analysisIdiopathic pulmonary fibrosisIPFpneumonia

Identifiers

PMID41658431
PMCPMC12877333

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