ArticleStem cells international2026
Regenerative Potential of Mesenchymal Stem Cells for Enhancing Uterine Health and Fertility in Repeat Breeder Dairy Cows.
Article in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Regenerative Potential of Mesenchymal Stem Cells for Enhancing Uterine Health and Fertility in Repeat Breeder Dairy Cows.Stem cells international · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suboptimal reproductive performance of repeat-breeding (RB) cows is a major challenge for the dairy industry, leading to higher costs, prolonged calving intervals, and reduced productivity, negatively impacting herd productivity and economic viability. Among the associated factors, endometrial degeneration stands out, characterized by the replacement of functional tissue with fibrotic tissue, compromising uterine receptivity. In this context, regenerative therapy using mesenchymal stem cells (MSCs) has emerged as a promising alternative. This study evaluated the effects of intrauterine MSC inoculation in RB cows diagnosed with endometrial degeneration. Nine crossbred cows (Gyr × Holstein) were included and underwent clinical, cytological, microbiological, histopathological, ultrasonographic, and molecular evaluations on day 0 (pre-treatment) and day 30 (post-treatment). The results demonstrated endometrial remodeling, with fibrotic tissue replaced by loose connective tissue, increased vascularization, and the presence of new groups of endometrial glands. Doppler ultrasonography revealed enhanced blood flow of the endometrial mucosa and thickening of the uterine wall after therapy. qRT-PCR analysis indicated reduced expression of pro-inflammatory cytokines (IL-1
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