Evidence map›Paper›PMID 41658356›Full record

ArticleFood chemistry: X2026

Balancing nutrition and safety: Acrylamide and HMF in biscuits from different cereal flours.

Marina Roldán, Marta Mesias, Francisco J Morales

Abstract read
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marina RoldánInstitute of Food Science, Technology and Nutrition, ICTAN-CSIC, José Antonio Novais 6, 28040 Madrid, Spain.
Marta MesiasInstitute of Food Science, Technology and Nutrition, ICTAN-CSIC, José Antonio Novais 6, 28040 Madrid, Spain.
Francisco J MoralesInstitute of Food Science, Technology and Nutrition, ICTAN-CSIC, José Antonio Novais 6, 28040 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated acrylamide and hydroxymethylfurfural (HMF) formation in biscuits made with refined and wholegrain flours from wheat, rye, spelt, oat, and buckwheat. Nutritional composition, dough properties, and biscuit characteristics were analyzed under different baking conditions. Wholegrain flours provided higher fiber and protein, but increased acrylamide precursors (free asparagine and reducing sugars). Acrylamide and HMF increased with baking temperature and time. Rye (1454 μg/kg) and buckwheat (146 μg/kg) showed the highest and lowest acrylamide levels, while wholegrain wheat (350.9 mg/kg) and refined wheat (37.6 mg/kg) had the highest and lowest HMF content. Although reference biscuits baked at 180 °C for 10 min remained below the European benchmark for acrylamide regardless of flour, more severe baking exceeded regulatory levels. These findings highlight the dual challenge of improving nutritional quality while controlling chemical risks, emphasizing the need for optimized reformulation and precise baking control to balance consumer health benefits with food safety.

Indexed as

AcrylamideBiscuitsCerealsHydroxymethylfurfuralPseudocerealsRisk

Identifiers

PMID41658356
PMCPMC12874612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.