ArticleOsteoarthritis and cartilage open2026
The infrapatellar fat pad mediates environmental exposure for clinical outcomes in knee osteoarthritis.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This cross-sectional study aimed to investigate whether the infrapatellar fat pad (IPFP) mediates the relationship between environmental exposures and clinical symptoms in patients with knee osteoarthritis (KOA). Methods: A total of 108 participants with KOA were included in this study, and environmental exposure data, including temperature, wind speed, and relative humidity, were obtained from local meteorological records. IPFP characteristics were quantitatively assessed using 3.0T magnetic resonance imaging (MRI), including morphometric and signal intensity (SI) parameters. Clinical symptoms were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Principal component analysis (PCA) was used to reduce dimensionality of IPFP MRI features. Mediation analysis was performed to examine whether IPFP parameters mediated the effect of environmental exposures on WOMAC scores. Results: PCA revealed that SI parameters accounted for 56.87 % of the total variance in IPFP features, while morphometric parameters explained 16.65 %. Correlation analysis showed that most SI parameters (e.g., mean SI, SD SI) were significantly associated with WOMAC scores (ranging from r = 0.20 to 0.49, p < 0.05), in contrast to morphometric measures. Environmental exposures, particularly lower temperatures, higher wind speed, and daily weather changes, were significantly correlated with increased SI. Mediation analysis demonstrated that IPFP MRI parameters, particularly SI parameters, significantly mediated the effects of environmental exposures on pain and total WOMAC scores. Conclusions: The IPFP, particularly its SI characteristics, mediates the relationship between environmental exposures and clinical symptoms in KOA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.