ArticleTherapeutic advances in musculoskeletal disease2026
Association between immune-inflammation index and the risk of gout attack: a systematic review and meta-analysis.
Article in Therapeutic advances in musculoskeletal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
Background: Evidence shows that gout attack is closely related to immune and inflammatory levels. However, there are limited evidence-based results for immune-inflammatory indices to predict gout attacks. Objectives: This study aimed to explore the predictive value of immune-inflammation index for acute gout. Design: Systematic review and meta-analysis. Data sources and methods: A systematic search was conducted based on Results: A total of 8 articles involving 2655 participants were included in this meta-analysis. The findings showed that both neutrophil-to-lymphocyte ratio (NLR; SMD: 0.75; 95% CI: 0.48-1.03) and platelet-lymphocyte ratio (PLR; SMD: 0.52; 95% CI: 0.24-0.79) showed significant value in predicting acute gout attacks. The sensitivity analysis results showed that both NLR and PLR were significantly stable in predicting acute gout attacks. Meanwhile, subgroup analyses were performed based on region, sample size, and age. The results showed that the predictive value of NLR and PLR for acute gout was significant in all subgroups, and age and sample size were potential sources of heterogeneity in PLR. However, no sources of heterogeneity were found in NLR. Conclusion: NLR and PLR are well-performed in predicting acute gout attacks. Given a lack of prospective studies, a limited number of related references, and significant heterogeneity, large-scale prospective studies are needed to verify the relationship between immune-inflammation index and gout attacks.
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