Evidence map›Paper›PMID 41658238›Full record

ArticleJHLT open2026

Outcomes and management strategies of pregnancies after heart and lung transplantation across Europe.

Jildau R Meinderts, Linda W van Laake, Dieuwertje Ruigrok, Olivier Manintveld, Jérôme Le Pavec, Michael Perch, Jens Gottlieb, Adelheid Görler, Robin Vos, Jesper M Magnusson and 12 more

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Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jildau R MeindertsDepartment of Nephrology, Groningen Institute for Organ Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Linda W van LaakeDepartment of Cardiology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Dieuwertje RuigrokDepartment of Pulmonology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Olivier ManintveldDepartment of Cardiology, Erasmus MC, Cardiovascular Institute, Thorax Center, Rotterdam, The Netherlands.
Jérôme Le PavecDepartment of Pulmonology, Marie Lannelongue Hospital, Le Plessis Robinson, France.
Michael PerchDepartment of Cardiology Section for Lung Transplantation, Heart Center, Rigshospitalet, Copenhagen, Denmark.
Jens GottliebDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research, Hannover, Germany.
Adelheid GörlerDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Robin VosDepartment of Respiratory Diseases, Department of CHROMETA, BREATHE, KU Leuven, University Hospitals Leuven, Leuven, Belgium.
Jesper M MagnussonDepartment of Respiratory Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Claire Merveilleux du VignauxDepartment of Respiratory Medicine, Hospices Civils de Lyon, Louis-Pradel Hospital, Lyon, France.
Aniko BohácsDepartment of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.
Balazs SaxHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Tanel LaisaarLung Clinic, Tartu University Hospital, Puusepa 8, 50406 Tartu, Estonia.
Vincent BunelAPHP.Nord-Université de Paris, Hôpital Bichat-Claude Bernard, Service de Pneumologie B et Transplantation Pulmonaire, Paris, France.
Margriet E GosselinkDepartment of Obstetrics and Gynaecology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Merel E HellemonsErasmus MC Transplant Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kevin DammanDepartment of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Jelmer R PrinsDepartment of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
A Titia LelyDepartment of Obstetrics and Gynaecology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Erik A M VerschuurenDepartment of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Margriet F C de JongDepartment of Nephrology, Groningen Institute for Organ Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Literature on pregnancy after heart and/or lung transplantation (heart transplantation (HTx), lung transplantation (LTx), heart lung transplantation (HLTx)) remains sparse. This study assessed short- and long-term outcomes of pregnancies post-thoracic organ transplantation across Europe and analyzed center management of these patients. Methods: European centers provided retrospective data on post-HTx/LTx pregnancies and center strategies for handling transplant recipients with a pregnancy wish. Descriptive statistics and linear regression analysis were used. Results: Forty-two females had 50 pregnancies across 12 European centers. Pregnancy-induced hypertension occurred in 50% (HTx), 28% (LTx), and 20% (HLTx), and preeclampsia in 19%, 16%, and 20%, respectively. Preterm birth (<37 weeks) occurred in 23% (HTx) and 68% (LTx), and birth weight <2,500 g in 8% and 58%, respectively. Live birth rate was 98%. In multivariable analysis, a trend for higher birth weight with higher pre-pregnancy estimated glomerular filtration rate was observed (B 13.3, 95% CI -1.7-28.4, Conclusions: We show reassuring pregnancy outcomes for post-HTx, LTx, and HLTx patients in an exclusive European cohort, despite high pregnancy complication rates. Graft function and overall maternal survival appear unaffected. We highlight differences in pregnancy management between centers and suggest development of a uniform approach.

Indexed as

Heart transplantationLong-term outcomesLung transplantationManagementPost-transplantation pregnancyPregnancy outcomes

Identifiers

PMID41658238
PMCPMC12874786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.