Evidence map›Paper›PMID 41658237›Full record

ArticleJHLT open2026

Beating heart transplantation: A single center's initial experience and propensity-matched analysis against national registry data.

Ashley Y Choi, Ntemena Kapula, Hao He, Ellelan Degife, Aravind Krishnan, Reza Ashrafi, Bridgette Han, Katherine Pines, Erik Henricksen, Stefan Elde and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ashley Y ChoiDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Ntemena KapulaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Hao HeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Ellelan DegifeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Aravind KrishnanDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Reza AshrafiDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Bridgette HanDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Katherine PinesDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Erik HenricksenDepartment of Transplant, Stanford Health Care, Stanford, CA.
Stefan EldeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Moeed FawadDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Jeffrey J TeutebergDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA.
Kiran K KhushDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA.
Helen LuikartDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA.
Chawannuch RuaengsriDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Yasuhiro ShudoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
John W MacArthurDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
William HiesingerDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Brandon A GuenthartDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Beating heart transplantation (BHT) was adopted to avoid an additional episode of cardioplegic arrest and reperfusion and reduce allograft ischemia-reperfusion injury. We sought to establish a direct comparison of outcomes between the first cohort of BHT recipients at our center and standard DCD recipients across the US. Methods: The UNOS registry was queried to identify adult recipients who underwent first-time isolated DCD HT between 12/2019-12/2023 (before the first BHT was performed outside of our center). All adult patients who underwent first-time isolated DCD BHT between 10/2022-9/2024 at our center were included. Nearest neighbor propensity-score matching was performed and groups were compared for 30-day survival, need for post-transplant mechanical circulatory support, major complications, length of stay, and 1-year survival. Results: A total of 1083 standard DCD recipients and 31 BHT recipients were identified. Before matching, more BHT recipients required pre-transplant IABP (29% vs 9.8%, p=0.003) and ECMO (6.5% vs 0.7%, p=0.029), had higher status on the waitlist (Status 1-3; 97.5% vs. 62%, p<0.001), and spent fewer days waiting [7(5,14) vs 30(9149) days, p<0.001). After matching, BHT recipients demonstrated similar 30-day survival (100% vs 98.3%, p>0.9) and improved 1-year graft survival (100% vs 83.9%, p<0.001) compared to standard DCD recipients. Conclusion: Despite BHT recipients being sicker than standard DCD recipients pre-transplant, their matched survival at 30-days was similar and graft survival was improved at 1-year post-transplant. While BHT may confer excellent early post-transplant outcomes, a larger sample size and longer-term follow-up are needed to confirm the survival benefit associated with BHT.

Indexed as

Beating heart transplantationDCD heart transplantationEx vivo heart perfusionIschemia reperfusion injuryPrimary graft dysfunction

Identifiers

PMID41658237
PMCPMC12882298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.