Evidence map›Paper›PMID 41658179›Full record

ArticleACS omega2026

Synthesis of a Cannabidiol Precursor: Experimental Challenges and DFT Insights into β‑Elimination Barriers.

Michael Bergami, Claudio Trapella, Greta Compagnin, Simona Felletti, Martina Catani, Silvia Pezzola, Federica Sabuzi, Pierluca Galloni, Paolo Marchetti, Virginia Cristofori and 2 more

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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael BergamiDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.
Claudio TrapellaIlluminati Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0002-6666-143X
Greta CompagninIlluminati Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.
Simona FellettiDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0002-4192-2074
Martina CataniIlluminati Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0003-4217-8766
Silvia PezzolaDepartment of Chemical Science and Technologies, University of Rome ″Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.
Federica SabuziDepartment of Chemical Science and Technologies, University of Rome ″Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-3757-0598
Pierluca GalloniDepartment of Chemical Science and Technologies, University of Rome ″Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-0941-1354
Paolo MarchettiIlluminati Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.
Virginia CristoforiIlluminati Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0002-6837-6042
Anna FantinatiDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0003-0437-5670
Davide IlluminatiIlluminati Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0002-0321-1941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of cannabidiol (CBD) from limonene derivatives involves a key β-elimination step that remains challenging to reproduce efficiently. In this work, we revisited a known racemic synthetic route to CBD and investigated the mechanistic origin of the low yield associated with the β-hydrogen elimination step. Alternative synthetic approaches were tested experimentally by comparing the traditional selenoxide-mediated pathway with a direct elimination attempt from bromohydrin intermediates. Despite optimization of reaction and workup conditions, β-elimination consistently failed, regenerating epoxide

Identifiers

PMID41658179
PMCPMC12878366

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.