ArticleACS omega2026
Development of Highly Stable Vitamin C Gummies Using Innovative In Situ Soft Sphere Integrated (ISSI) Liposomal Technology: Characterization and In Vitro Release Studies.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gummies: From Confectionery to Functional Hydrogel-Based Bioactive Delivery Systems.Gels (Basel, Switzerland) · 2026Review
- Unconventional Ingredients in Gummy Reformulation: A Review of Nutritional, Functional, and Technological Implications.Foods (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin-enriched gummies are gaining popularity due to their convenience and consumer appeal; however, incorporating water-soluble and unstable vitamins such as vitamin C remains challenging because of its poor stability and rapid degradation during processing. This study aimed to develop a heat-stable liposomal vitamin C gummy (LVC gummy) using In Situ Soft Sphere Integrated (ISSI) technology with a xyloglucan/trehalose/citric acid cross-linked polymeric matrix. The ISSI system enhanced the thermal, structural, and chemical stabilities of vitamin C during gummy preparation and storage. Characterization by transmission and scanning electron microscopy, FTIR, particle size, and zeta potential analysis confirmed a uniform vesicle formation and stable polymeric coating. The LVC gummies showed desirable physicochemical properties, including optimal dispersion, swelling behavior, and low water activity. Accelerated stability studies demonstrated improved vitamin C retention, while in vitro release testing indicated minimal release under gastric conditions and sustained release in the intestinal phase compared to conventional gummies. Overall, this approach offers a robust and consumer-acceptable delivery system for vitamin C, providing a practical solution for enhancing vitamin stability in functional foods and nutraceuticals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.