Glutathione-Responsive Polymeric Nanosystem for the Codelivery of Iron and Doxorubicin to Promote Synergistic Ferroptosis and Chemotherapy in Cancer Treatment.

Anna Wang, Keying Cai, Zhixin Lin, Jingwen Xue, Juan Sun

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Stimuli-responsive bioengineered platforms for precision cancer therapy.Frontiers in bioengineering and biotechnology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna WangSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, P. R. China.ORCID https://orcid.org/0009-0000-0386-6625

Keying CaiSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, P. R. China.

Zhixin LinSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, P. R. China.

Jingwen XueSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, P. R. China.

Juan SunSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, P. R. China.ORCID https://orcid.org/0000-0001-6099-2193

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective cancer therapy remains challenging due to poor tumor specificity, low drug bioavailability, and systemic toxicity of conventional treatments. Herein, we develop a glutathione (GSH)-responsive nanodrug, PEG-SS-PCL@Fe-DOX, which synergistically combines ferroptosis and chemotherapy to achieve enhanced antitumor efficacy. This nanosystem employs a disulfide-linked amphiphilic polymer (PEG-SS-PCL) to encapsulate the Fe-DOX complex, enabling GSH-triggered, tumor-specific drug release. In the tumor microenvironment, cleavage of disulfide bonds facilitates the release of DOX and Fe

Identifiers

PMID41658161

DOI10.1021/acsomega.5c08927

PMCPMC12878456

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.