ArticleACS omega2026
Aldehyde-Functionalized Cellulose Nanofiber Hydrogels for pH-Sensitive Drug Delivery via Dynamic Imine Bonding.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cellulose and Its Derivatives in Drug Delivery: Recent Advances and Applications.Pharmaceutics · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We designed a hydrogel system that not only responds to disease-relevant pH conditions but also allows precise control over the network density and drug release via acid-catalyzed imine bond formation. By comparing drugs with and without amine functionalities (DOX vs α-MS) and evaluating the effect of an acid catalyst on cross-linking and drug diffusion, we provide mechanistic insights into the rational design of cellulose-based smart hydrogels. Drug release experiments revealed pH-dependent behavior with accelerated release under acidic conditions due to imine bond hydrolysis. The presence of an acid catalyst enhanced cross-linking between aldehyde-functionalized TEMPO-oxidized cellulose nanofibers (A-TOCNF) and glycol chitosan (GC), leading to a denser network and suppressing DOX release. SEM analysis showed that acid-catalyzed samples exhibited more compact fibrous structures, correlating with higher mechanical stability, as confirmed by AFM-based Young's modulus measurements. WST-8 assays using Colon26 cells validated the biocompatibility of the drug-free hydrogel and the anticancer efficacy of DOX-loaded hydrogels. Overall, this hydrogel system demonstrates excellent potential as a biodegradable, site-specific drug delivery platform that is responsive to disease-associated pH conditions. Given that over 40% of therapeutic compounds contain amine groups, the platform offers broad applicability for targeted and sustained drug delivery.
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Registered trials
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