ArticleACS omega2026
Synergistic Effects of Ceramic Fillers and NaOH Treatment on Bioactivity of 3D-Printed Poly(ε-caprolactone) Scaffolds for Periodontal Tissue Regeneration.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Protein adsorption at material interface: mechanistic design framework for engineering ceramic scaffolds for bone repair applications.Biomedical engineering online · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porous scaffolds composed of poly-(ε-caprolactone) (PCL) and ceramic fillershydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP)were fabricated via extrusion-based additive manufacturing for bone tissue engineering applications. The scaffolds exhibited interconnected pores (∼400 μm) in a 0°-90° deposition pattern and were subjected to alkaline surface treatment with 1 M NaOH to increase surface roughness and promote partial exposure of embedded ceramic particles. Characterization included rheological analysis to assess processability, thermal evaluation via thermogravimetric analysis and differential scanning calorimetry, and surface morphology using scanning electron microscopy, energy-dispersive spectroscopy, and atomic force microscopy. Filler particle size was characterized, confirming submicron dimensions favorable for bioactive interaction; however, distribution within the polymer matrix was not directly evaluated. Mechanical testing under uniaxial compression revealed that ceramic addition increased stiffness and compressive strength. Protein adsorption assays indicated a significant increase in surface bioactivity following NaOH treatment. In vitro assays with MC3T3-E1 preosteoblastic cells confirmed good cytocompatibility, cell adhesion, and proliferation. Collectively, these findings suggest that the combination of ceramic incorporation and surface modification enhances both mechanical and biological performance, supporting the potential application of PCL-based scaffolds in bone regeneration strategies.
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Registered trials
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