Evidence map›Paper›PMID 41658042›Full record

ArticleJournal of diabetes research2026

Metabolites in Early-Mid Pregnancy Mediate the Association Between Prepregnancy Body Mass Index and Risk of Gestational Diabetes Mellitus.

Suna Wang, Yanwei Zheng, Mingjuan Luo, Wei Chen, Jingyi Guo, Rongzhen Jiang, Xiangtian Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suna WangClinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.ORCID https://orcid.org/0000-0002-1545-3227
Yanwei ZhengDepartment of Obstetric and Gynaecology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.ORCID https://orcid.org/0000-0002-4433-5705
Mingjuan LuoDepartment of Endocrinology and Metabolism, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, hku-szh.org.ORCID https://orcid.org/0000-0002-8988-517X
Wei ChenClinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.ORCID https://orcid.org/0009-0005-1290-4853
Jingyi GuoClinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.ORCID https://orcid.org/0000-0002-9514-7157
Rongzhen JiangDepartment of Obstetric and Gynaecology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.ORCID https://orcid.org/0009-0008-9406-3745
Xiangtian YuClinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.ORCID https://orcid.org/0000-0002-9571-3446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The study is aimed at identifying the shared metabolites in early-mid pregnancy associated with prepregnancy body mass index (pBMI) and subsequent gestational diabetes mellitus (GDM) risk and at exploring the mediating role of metabolites. Methods: One hundred pregnant women with GDM and 100 matched controls were enrolled in the study. Serum samples were collected in 10-20 weeks' gestation and used for targeted metabolomic assay measurement. The associations among pBMI, metabolites, and GDM were investigated using linear regression and logistic regression models. Mediation analysis was conducted to evaluate the mediating effect of individual metabolite and clustered latent variable (LV) on the association of pBMI with GDM. Results: We identified eight metabolites significantly associated with both pBMI and GDM, which contained three organic acids, three acylcarnitines, and two fatty acids. Mediation analysis found five individual metabolites and two clustered LVs exhibited significant mediation effects in the association between pBMI and GDM risk. LV1 showed mediated proportions of 24.0%, which represented as organic acids and enriched in branched-chain amino acid biosynthesis. LV2 showed mediated proportions of 19.1%, which represented as acylcarnitines and enriched in linoleic acid metabolism. Furthermore, we validated the mediating role of branched-chain amino acids during the OGTT period. Conclusion: The association between pBMI and GDM risk was attributed to serum metabolites in early-mid pregnancy, especially metabolites related to branched-chain amino acid biosynthesis.

Indexed as

Body Mass IndexDiabetes, GestationalPregnancy Trimester, SecondAdultAmino Acids, Branched-ChainBiomarkersCarnitineCase-Control StudiesFemaleHumansMetabolomicsPregnancyRisk FactorsacylcarnitineAmino Acids, Branched-ChainBiomarkersCarnitinegestational diabetes mellitusmediation analysismetabolomicsprepregnancy body mass index

Identifiers

PMID41658042
PMCPMC12872595

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.