Evidence map›Paper›PMID 41658029›Full record

ArticleJournal of community hospital internal medicine perspectives2025

Utilization of Antiviral Treatment for Hospitalized Patients With Mild-to-moderate COVID-19 at High Risk for Disease Progression.

Michael P Iannetti, Katie Barnes, Stephen Varga, Suzanne Kemper, Elaine D Mattox

Abstract read
In one paragraph

Article in Journal of community hospital internal medicine perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael P IannettiInternal Medicine, Charleston Area Medical Center, 1220 Lee Street East, Suite 110, Charleston, WV 25301, United States.
Katie BarnesWest Virginia University, Charleston Division, 3200 MacCorkle Ave SE, Charleston, WV 25304, United States.
Stephen VargaWayne State University, SJMO Medical Office Building, Pontiac, MI 48341, United States.
Suzanne KemperCharleston Area Medical Center Institute for Academic Research, 3110 MacCorkle Ave SE, Charleston, WV 25304, United States.
Elaine D MattoxCharleston Area Medical Center Institute for Academic Research, 3110 MacCorkle Ave SE, Charleston, WV 25304, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinicians frequently encounter patients in the hospital with mild-to-moderate COVID-19 who are at high risk for disease progression. Antiviral drugs reduce the rate of progression to severe COVID-19 when given to these patients within 5-7 days of symptom onset. To look at the utilization of antiviral medications in hospitalized patients with mild-to-moderate COVID-19, a detailed chart review was conducted of 500 randomly selected patients from the Charleston Area Medical Center COVID-19 Registry. We identified 124 patients with mild-to-moderate COVID-19 who were eligible for antiviral treatment. Only 41 of the 124 patients (33.1 %) received antiviral treatment. Providers listed mild symptoms as the most common reason (74.7 %) that antiviral treatment was not started. These findings show that antiviral medications are underutilized in treating high-risk hospitalized patients with mild-to-moderate COVID-19 to prevent disease progression.

Indexed as

AntiviralsCOVID-19Nirmatrelvir/ritonavirRemdesivirSARS-CoV-2

Identifiers

PMID41658029
PMCPMC12880934

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.