Evidence map›Paper›PMID 41658015›Full record

ArticleFrontiers in aging neuroscience2026

Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis.

Shuoxi Liao, Hui Yang, Li Song, Lingli Shi, Zhike Lan, Wenrong Zhao, Zeyan Bao, Qiongli Hu, Xiaomei Tang, Sidian Zhuang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shuoxi LiaoDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Hui YangDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Li SongDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Lingli ShiDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Zhike LanDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Wenrong ZhaoDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Zeyan BaoDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Qiongli HuDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Xiaomei TangDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Sidian ZhuangDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.
Huidi WangMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shuisheng ZhongDepartment of Neurology, Guangdong Sanjiu Brain Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Obstructive sleep apnea syndrome (OSAS) is positively associated with increased risks of ischemic stroke. Patients with stroke exhibit remarkable gut microbiota dysbiosis. However, the impact of OSAS on gut microbiota of patients with symptomatic intracranial atherosclerotic stenosis (sICAS), one of the most common causes of stroke, remains unknown. Methods: This study included patients with sICAS, the severity of OSAS was defined by the apnea-hypopnea index (AHI). AHI < 5 was considered no sleep apnea, AHI 5-15 was defined as mild OSAS, AHI 15-30 as moderate OSAS, and AHI > 30 as severe OSAS. Fecal samples were collected and subjected to 16 s rRNA gene sequencing. PICRUSt2 was used to predict the functional properties of the bacterial communities. Results: In total, 99 sICAS patients were included, with No-OSAS ( Conclusion: OSAS is associated with gut dysbiosis and altered microbial metabolic functions in patients with sICAS.

Indexed as

dysbiosisgut microbiomemetabolic functionobstructive sleep apnea syndromesymptomatic intracranial atherosclerotic stenosis

Identifiers

PMID41658015
PMCPMC12872767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.