Evidence map›Paper›PMID 41657949›Full record

ArticleBioactive materials2026

Geometry-driven immunomodulation in 3D-printed bioceramics: Negative curvature promotes macrophage M2 polarization via Ras-MAPK/HIF-1α signaling for vascularized osteogenesis.

Qiji Lu, Yudi Kuang, Jingjing Diao, Jiaqian Zheng, Naru Zhao, Chang Du, Yingjun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiji LuSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, PR China.
Yudi KuangGuangdong Institute of Advanced Biomaterials and Medical Devices, Guangzhou, 510535, PR China.
Jingjing DiaoSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, PR China.
Jiaqian ZhengSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Naru ZhaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Chang DuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Yingjun WangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The geometric features of bioactive scaffolds are biophysical cues regulate cell fate, but their immunomodulatory potential in bone regeneration is yet to be determined. Growing evidence suggests that surface curvature is a potent regulator of cellular behaviours and osteogenesis. Therefore, we quantitatively decoded this underlying mechanism by identifying Gaussian curvature(

Indexed as

Bone regenerationGaussian curvatureHigh-throughput screeningImmunomodulatory biomaterialsMacrophage polarization

Identifiers

PMID41657949
PMCPMC12874619

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.