Evidence map›Paper›PMID 41657898›Full record

ArticleFrontiers in microbiology2026

Unraveling the mechanism of mulberry leaf in alleviating hyperuricemia: key role of kaempferol by modulating AKT pathway and gut-kidney axis.

Jiawei Huang, Qianqian Wang, Xiaowen Guo, Yuanyuan Niu, Junhong Huang, Boyi Zhang, Zixuan Guo, Zilong Wang, Shuying Feng

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiawei Huang *Medical College, Henan University of Chinese Medicine, Zhengzhou, China.
Qianqian Wang *Medical College, Henan University of Chinese Medicine, Zhengzhou, China.
Xiaowen Guo *Medical College, Henan University of Chinese Medicine, Zhengzhou, China.
Yuanyuan NiuMedical College, Henan University of Chinese Medicine, Zhengzhou, China.
Junhong HuangMedical College, Henan University of Chinese Medicine, Zhengzhou, China.
Boyi ZhangMedical College, Henan University of Chinese Medicine, Zhengzhou, China.
Zixuan GuoMedical College, Henan University of Chinese Medicine, Zhengzhou, China.
Zilong WangMedical College, Henan University of Chinese Medicine, Zhengzhou, China.
Shuying FengMedical College, Henan University of Chinese Medicine, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mulberry leaf ( Methods: Results: Kaempferol was identified as the principal bioactive compound, while the key targets were AKT1 and TNF. Molecular docking and dynamics simulations revealed that AKT1-kaempferol and TNF-kaempferol complexes showed strong and stable binding pattern after a 100 ns simulation. Conclusion: Kaempferol may regulate UA metabolism and inflammatory injury by modulating the AKT signaling pathway, and exert its effects on the gut-kidney axis and restoring gut microbiota composition.

Indexed as

16S rRNAsequencingAkt signaling pathwayhyperuricemiain vivo studykaempferolmoleculardynamics simulationsnetwork pharmacology

Identifiers

PMID41657898
PMCPMC12872837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.