Evidence map›Paper›PMID 41657783›Full record

ArticleAmerican journal of cancer research2026

CCT5 as a candidate biomarker in bladder cancer: functional validation and mechanistic clues.

Xiaojun Zhang, Yuqiang Fu, Yuelin Du, Wei Xiong, Jieneng Wang, Helin Zhang, Yao Luo, Yanzong Zhao, Panfeng Shang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaojun ZhangDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
Yuqiang FuDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
Yuelin DuDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
Wei XiongDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
Jieneng WangDepartment of Cardiovascular, The First Hospital of Lanzhou University Lanzhou 730000, Gansu, China.
Helin ZhangDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
Yao LuoDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
Yanzong ZhaoDepartment of Urology, The First Hospital of Lanzhou University Lanzhou 730000, Gansu, China.
Panfeng ShangDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CCT5, a subunit of the chaperonin-containing TCP1 complex, has been implicated in the development of various malignancies. However, its role in bladder cancer remains undefined. This study investigated the functional contribution of CCT5 and its association with Hippo/YAP signaling. Using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), CCT5 expression and its prognostic significance were analyzed. Single-cell and spatial transcriptomics were employed to explore expression patterns and cellular heterogeneity. Functional assessments were conducted

Indexed as

apoptosisbladder cancerCCT5cell cycleHippo/YAP signaling

Identifiers

PMID41657783
PMCPMC12877373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.