Evidence map›Paper›PMID 41657707›Full record

ArticleNeural plasticity2026

Berberine Alleviates Lipopolysaccharide-Induced Impairments in Neuroplasticity and Spatial Memory by Modulating Microglial Polarization via MAPK Signaling Inhibition.

Lirong Jiang, Ruiyi Liao, Jiaxin Wang, Yuan Yang, Jiaojiao Sun, Li Liu, Yiwei Wang, Wei Dong, Yang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lirong JiangDepartment of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0009-0000-7409-5557
Ruiyi LiaoDepartment of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0009-0003-7800-604X
Jiaxin WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0009-0004-6072-5780
Yuan YangKey Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0009-0006-3918-1330
Jiaojiao SunDepartment of Medical Imaging Technology, Nanyang Medical College, Nanyang, 473004, Henan, China.ORCID 0000-0001-7727-8463
Li LiuDepartment of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0009-0000-0130-0660
Yiwei WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0000-0003-2679-8623
Wei DongKey Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0000-0002-8151-9407
Yang YuDepartment of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China, swmu.edu.cn.ORCID 0000-0001-7085-8289

Funding

Open Fund of Key Laboratory of Medical ElectrophysiologySichuan Science and Technology ProgramTechnological Plan Program of Luzhou
6 · The paper itself

Abstract

Neuroinflammation-induced cognitive impairment is characterized by a continued decline in memory, executive functioning, and information-processing abilities. Although berberine (BBR) exhibits anti-inflammatory and neuroprotective properties, its ability to mitigate cognitive deficits by regulating microglial-mediated neuroinflammation remains incompletely understood. To investigate the potential of BBR in mitigating microglial-mediated neuroinflammation and its detrimental effects on neuroplasticity and spatial memory, a mouse model was established through intrahippocampal microinjection of lipopolysaccharide (LPS). The results showed that BBR pretreatment significantly improved cognitive performance, suppressed microglial activation, reduced hippocampal neuronal damage, and increased the density of functional dendritic spines. Mechanistic analysis revealed that BBR treatment inhibited the phosphorylation of key proteins in the MAPK signaling pathway within microglia. These findings suggest that BBR is a promising therapeutic agent for mitigating neuroinflammation-induced cognitive impairment and provide significant evidence for its potential application in treating inflammation-related cognitive deficits.

Indexed as

BerberineCognitive DysfunctionMAP Kinase Signaling SystemMicrogliaNeuronal PlasticitySpatial MemoryAnimalsHippocampusLipopolysaccharidesMaleMiceMice, Inbred C57BLNeuroinflammatory DiseasesNeuroprotective AgentsBerberineLipopolysaccharidesNeuroprotective Agentsberberinecognitive impairmentMAPK signalingmicroglianeuroinflammation

Identifiers

PMID41657707
PMCPMC12873632

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.