Evidence map›Paper›PMID 41657614›Full record

ArticleBioinformation2025

Arsenicum iodatum and arseicum album induces apoptosis and autophagy in glioblastoma multiforme.

Ankit Pateriya, Pratima Gupta, Ashutosh Shrivastava, Dhruv Varshney, Sreyanko Sadhukhan, Manendra Singh Tomar, Arun Kumar Gupta, Naibedya Chattopadhyay, Rohit Anthony Sinha

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In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ankit PateriyaCenter for Advance Research, Faculty of Medicine, King George's Medical University, Lucknow-226003, Uttar Pradesh, India.
Pratima GuptaDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India.
Ashutosh ShrivastavaCenter for Advance Research, Faculty of Medicine, King George's Medical University, Lucknow-226003, Uttar Pradesh, India.
Dhruv VarshneyCenter for Advance Research, Faculty of Medicine, King George's Medical University, Lucknow-226003, Uttar Pradesh, India.
Sreyanko SadhukhanDivision of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.
Manendra Singh TomarCenter for Advance Research, Faculty of Medicine, King George's Medical University, Lucknow-226003, Uttar Pradesh, India.
Arun Kumar GuptaHomeopathic Drug Research Institute, Lucknow-226010, Uttar Pradesh, India.
Naibedya ChattopadhyayDivision of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.
Rohit Anthony SinhaDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a highly aggressive and treatment-resistant brain tumor, highlighting the need for novel therapeutic strategies. Therefore, it is of interest to investigate the anti-cancer effects of Arsenicum iodatum and Arsenicum album in U87 glioblastoma cells at 6C, 12C and 30C potencies. Both preparations induced apoptosis, confirmed by TUNEL along with the caspase-3 assays and triggered autophagy, evidenced by reduced p62 levels. Inhibition of autophagy enhanced cytotoxicity, indicating its protective role in GBM cells. Thus, we show that Arsenicum iodatum and Arsenicum album may serve as complementary candidates for GBM therapy, warranting further

Indexed as

apoptosisautophagyGlioblastoma multiformehomeopathic drugs

Identifiers

PMID41657614
PMCPMC12880139

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