ArticleBioinformation2025
Pharmacogenomics of surgical stress response in elective abdominal surgeries.
Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
The variability in surgical stress response among patients undergoing elective abdominal surgeries remains inadequately understood, particularly in relation to genetic polymorphisms influencing drug metabolism and pain modulation. Hence, this study explored the association between key pharmacogenetic variants (CYP2D6, CYP3A4, OPRM1 and COMT) and biomarkers of surgical stress response. A total of 240 patients were evaluated, with half receiving pharmacogenomic-guided perioperative management. Significant differences were observed in IL-6 levels, opioid requirements and complication rates between genotypic groups. Pharmacogenomic-guided therapy effectively reduced postoperative complications and improved recovery, underscoring its potential for personalized surgical care.
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