Evidence map›Paper›PMID 41657583›Full record

Trial reportFrontiers in medicine2025

Effects of remimazolam vs. an etomidate-propofol mixture on postoperative cognitive function in elderly female patients undergoing radical mastectomy for breast cancer: a randomized controlled trial.

Wenzhe Shen, Lili Li, Ziyi Zhang, Minghong Liu, Jun Shi

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenzhe ShenGraduate School of Bengbu Medical University, Bengbu, Anhui, China.
Lili LiGraduate School of Bengbu Medical University, Bengbu, Anhui, China.
Ziyi ZhangGraduate School of Bengbu Medical University, Bengbu, Anhui, China.
Minghong LiuDepartment of Anesthesiology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, Anhui, China.
Jun ShiDepartment of Anesthesiology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate remimazolam's anesthetic efficacy and impact on postoperative cognitive function in breast cancer patients undergoing radical mastectomy. Methods: A total of 80 patients were randomized into two groups: Group R (remimazolam, Results: Baseline characteristics were comparable between groups ( Conclusion: Remimazolam provides effective anesthesia for elderly female patients undergoing radical mastectomy, offering superior hemodynamic stability at key time points, faster recovery, fewer adverse events, and significantly better preservation of early postoperative cognitive function compared with an etomidate-propofol mixture. Clinical trial registration number: identifier ChiCTR2500106237.

Indexed as

analgesiabreast cancercognitive functiongeneral anesthesiaremimazolam

Identifiers

PMID41657583
PMCPMC12872828

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.