Evidence map›Paper›PMID 41657552›Full record

ArticleFrontiers in physiology2026

Loss of SPECC1L in cranial neural crest cells results in increased hedgehog signaling and frontonasal dysplasia.

An J Tran, Brittany M Hufft-Martinez, Dana N Thalman, Lorena Maili, Sean A McKinney, Jeremy P Goering, Paul A Trainor, Irfan Saadi

Abstract read
In one paragraph

Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

An J Tran *Department of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, United States.
Brittany M Hufft-Martinez *Department of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, United States.
Dana N ThalmanDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, United States.
Lorena MailiStowers Institute for Medical Research, Kansas City, MO, United States.
Sean A McKinneyStowers Institute for Medical Research, Kansas City, MO, United States.
Jeremy P GoeringDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, United States.
Paul A TrainorDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, United States.
Irfan SaadiDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, United States.

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ABRAHAMSON, DALE R · 2017 to 2021
$5.6M
NRSA Training CoreTL1TR002368 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jennifer Lynn Goldman, NICOLE L NOLLEN · 2017 to 2026
$4.0M
Role of SPECC1L cytoskeletal protein in palate elevation dynamicsR01DE032825 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irfan Saadi · 2023 to 2026
$2.4M
The Role of SPECC1L cytoskeletal protein in craniofacial development and malformationR01DE026172 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2016 to 2020
$1.9M
Super resolution microscope for the imaging core facilityS10OD023625 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NISHIMUNE, HIROSHI · 2019 to 2019
$987k
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
Investigating the protective effect of maternal Thm1 heterozygosity against cleft palateR21DE032515 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN, TRAN, PAMELA VIVIAN · 2023 to 2024
$426k
In utero rescue of cleft palate using maternal administration of folic acidR21DE032742 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN, TRAN, PAMELA VIVIAN · 2023 to 2024
$426k
The role of rRNA transcription and ribosome biogenesis in neural crest progenitors and stem cells during embryonic and postnatal craniofacial developmentF32DE033617 · NIDCR · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI Lorena Maili · 2023 to 2026
$239k
NCATS NIH HHS TL1 TR002368NICHD NIH HHS U54 HD090216NIDCR NIH HHS F32 DE033617NIDCR NIH HHS R01 DE026172NIDCR NIH HHS R01 DE032825NIDCR NIH HHS R21 DE032515NIDCR NIH HHS R21 DE032742NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM122731NIH HHS S10 OD023625NIH HHS S10 OD032207
6 · The paper itself

Abstract

SPECC1L encodes a cytoskeletal scaffolding protein that interacts with filamentous actin, microtubules, and cell junctional components. In humans, autosomal dominant mutations in

Indexed as

cranial mesenchymecraniofacial developmentfrontonasal dysplasiahedgehog signalingprimary cilia

Identifiers

PMID41657552
PMCPMC12873473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.