ArticleFrontiers in cardiovascular medicine2026
The correlation between reactive hyperemia index and endothelial dysfunction markers in patients with hypertension and obstructive sleep apnea syndrome: a cross-sectional study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Currently, there is a lack of clinical studies on how to stratify endothelial dysfunction based on the severity of co-existing hypertension and OSAHS. This evidence gap hinders clinicians' ability to accurately assess disease burden and determine the best timing and intensity of intervention for these high-risk patients. This study aimed to investigate the impact of hypertension combined with OSAHS on vascular endothelial function. Methods: Patients aged 35-60 years with hypertension and OSAHS were consecutively recruited from the outpatient department of the Department of Cardiology at the Chengdu Pidu District People's Hospital, from July 1, 2023, to December 31, 2023. AHI, RHI and endothelial damage-related markers [Von Willebrand Factor (VWF), Vascular Endothelial Growth Factor (VEGF), and Endothelial Microparticles (EMPs)] were measured. Routine examination data were collected. Results: The correlation analysis between AHI, RHI, and hypertension grade and hypertension stage showed correlation coefficients less than 0.2, indicating almost no linear relationship. The correlation coefficient between AHI and RHI was -0.58 ( Conclusion: In patients with hypertension combined with OSAHS, RHI can be used as an important indicator in routine tests of vascular endothelial function to predict the degree of vascular endothelial injury.
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