Evidence map›Paper›PMID 41657379›Full record

ReviewACS polymers Au2025

Bacterial Nanocellulose Functionalization for Smart Bioelectronics: Integration into Biosensing, Neural Interfaces, and Tissue Engineering.

Maurelio Cabo, Farbod Ebrahimi, Jeffrey R Alston, Rutujaa Kulkarni, Samir Kattel, Kristen Dellinger, Dennis LaJeunesse

Abstract readReview
In one paragraph

Review in ACS polymers Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maurelio CaboDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, The University of North Carolina at Greensboro, Greensboro, North Carolina 27401, United States.ORCID https://orcid.org/0000-0003-2339-7998
Farbod EbrahimiDepartment of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T University, Greensboro, North Carolina 27401, United States.
Jeffrey R AlstonDepartment of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T University, Greensboro, North Carolina 27401, United States.ORCID https://orcid.org/0000-0002-4177-0648
Rutujaa KulkarniDepartment of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T University, Greensboro, North Carolina 27401, United States.
Samir KattelDepartment of Applied Science and Technology, North Carolina Agricultural and Technical State University, Greensboro, North Carolina 27411, United States.ORCID https://orcid.org/0009-0001-1832-6450
Kristen DellingerDepartment of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T University, Greensboro, North Carolina 27401, United States.ORCID https://orcid.org/0000-0001-8193-7564
Dennis LaJeunesseDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, The University of North Carolina at Greensboro, Greensboro, North Carolina 27401, United States.ORCID https://orcid.org/0000-0001-5049-8968

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial nanocellulose (BNC), a renewable biopolymer biosynthesized by specific bacterial strains, exhibits exceptional mechanical strength, water retention, and biocompatibility due to its nanofibrillar 3D architecture and high purity. Functionalizing BNC with conductive polymers, metal nanoparticles, enzymes, and peptides unlocks its potential for diverse applications in smart bioelectronics, including biosensors, neural interfaces, and tissue engineering. This review presents a comprehensive analysis of recent strategies for tuning BNC's electrical, optical, biological, and mechanical properties to meet the evolving demands of next-generation biomedical and wearable devices. We discuss a broad range of functionalization methodsfrom in situ nanoparticle synthesis and electrostatic assembly to cross-linking and doping with ionic liquidsand explore their role in enhancing conductivity, stimuli-responsiveness, and cellular interactions. Furthermore, we examine BNC-based nanocomposites designed for biosensing, wound healing, optoelectronic sensing, and flexible implantable systems. The review concludes by outlining current key hurdles including scalability, device integration, long-term stability, and stringent regulatory requirements for safe production, use, and clinical translation, while uniquely positioning BNC through a cross-domain comparison of biomedical and electronic applications, complemented by techno-economic insights into scale-up, cost, and regulatory challenges.

Indexed as

bacterial nanocellulosebiomaterialsbiomedicalbiosensorsdrug delivery systemsnanocompositesneural interfacessmart bioelectronicstissue engineering

Identifiers

PMID41657379
PMCPMC12874158

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.