Bactericidal Activities of Copolymers Incorporating Formylphenyl Motif for Targeting Surface Proteins.

Esteban Bautista, Melody Sun, Michael Colwin, Albert R La Spada, Seunghyun Sim

Abstract read

In one paragraph

Article in ACS polymers Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Esteban BautistaDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.

Melody SunDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0009-0008-6144-8059

Michael ColwinDepartments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California Irvine, Irvine, California 92697, United States.

Albert R La SpadaDepartments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California Irvine, Irvine, California 92697, United States.

Seunghyun SimDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0002-4232-5917

Funding

Spatially Structured Synthetic Consortia of Microbes to Understand and Engineer Cells in 3D EnvironmentsR35GM150770 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seunghyun Sim · 2023 to 2026

$1.5M

NIGMS NIH HHS R35 GM150770

6 · The paper itself

Abstract

We developed a set of intrinsic antimicrobial copolymers equipped with a dual-binding mechanism for the bacterial cell surface, targeting both the anionic bacterial membrane through electrostatic interactions and surface proteins through reversible imine formation. These copolymers, containing formylphenyl and quaternary ammonium functional groups, were systematically evaluated for their biological activity as the chemical composition and architecture were varied. These bactericidal polymers exhibit potent antimicrobial activity in NB media against both

Indexed as

AMRantimicrobial polymerscopolymersformylphenyl motifquaternary ammonium

Identifiers

PMID41657378

DOI10.1021/acspolymersau.5c00095

PMCPMC12874151

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.