ArticleFrontiers in human neuroscience2025
Randomized prenatal and postnatal nutrient supplementation shows no long-term impact on cortical gray matter in Ghanaian children.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Maternal and child undernutrition are linked to atypical brain development in children. Provision of pre- and post-natal small-quantity lipid-based nutrient supplements (SQ-LNS) has been shown to positively impact children's growth and development. It is unknown, however, whether SQ-LNS affects child brain morphology. Methods: The present study used data from the International Lipid-based Nutrient Supplements randomized controlled trial in Ghana. Participants were 231 children ( Results: Whole-brain analyses revealed no significant differences between groups in total gray matter volume or cortical gray matter thickness or volume. Cortical ROI analyses showed the SQ-LNS versus control group had greater right caudal anterior cingulate cortex (ACC) thickness [mean (95%CI): 2.78 (2.73, 2.84) vs. 2.72 (2.67, 2.77); effect size = 0.21] and reduced left rostral ACC volume [2575.1 (2477.3, 2672.8) vs. 2678.74 (2568.7, 2788.8); effect size = 0.18]. Subcortical ROI analyses showed the SQ-LNS versus control group had greater volume of the left pallidus [1794.45 (1759.10, 1829.80) vs. 1726.13 (1685.05, 1767.21); effect size = 0.33] and right nucleus accumbens [751.54 (729.83, 773.24) vs. 705.73 (684.21, 727.24); effect size = 0.39]. Significant group differences did not hold after correction for multiple comparisons. Discussion: In this cohort, pre- and post-natal SQ-LNS supplementation did not significantly alter total or cortical gray matter thickness and volume at 10 years, though secondary ROI analyses indicated subtle, non-robust differences in selected regions.
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