Evidence map›Paper›PMID 41657334›Full record

ArticleThe Laryngoscope2026

Fluorescence Guidance Reduces Operative Time for Sentinel Lymph Node Biopsy in the Head and Neck.

Morgan Davis Mills, Sophie S Jang, Ryotaro Ogawa, Edward Ashworth, Christopher V Barback, David J Hall, David R Vera, Theresa Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Morgan Davis MillsDepartment of Otolaryngology, Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.
Sophie S JangDepartment of Otolaryngology, Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.
Ryotaro OgawaUCSD Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
Edward AshworthUCSD Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
Christopher V BarbackUCSD Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
David J HallUCSD Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
David R VeraUCSD Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
Theresa GuoDepartment of Otolaryngology, Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-1689-3275

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Identification of splice variant derived neo-antigens in head and neck squamous cell carcinoma as targets for tumor vaccine therapyK08CA276999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Theresa Guo · 2024 to 2026
$706k
American Cancer Society IRG-19-230-48-IRGNCATS NIH HHS KL2 TR001444NCI NIH HHS K08 CA276999NCI NIH HHS P30 CA023100NIH HHS 1KL2TR001444
6 · The paper itself

Abstract

objectivePrior studies have demonstrated the feasibility of fluorescently labeled tilmanocept for sentinel lymph node biopsy (SLNB) in the oral cavity. We evaluated the added value of fluorescently labeled tilmanocept in sentinel lymph node biopsy (SLNB) of the oral cavity compared to gamma probe.

methodsHealthy male New Zealand white rabbits received oral cavity injections of radioactive (Technetium 99m) and fluorescently (IRDye800) conjugated tilmanocept followed by either fluorescence guided (n = 14) or gamma probe guided (n = 14) SLNB performed 1 h, 48 h, or 5 days postinjection. Duration of the SLNB performed by two individuals was measured and compared using the two methods.

resultsFluorescence guidance resulted in a 1.8-fold reduction in time of SLN removal (median 104 vs. 191 s, p = 0.05). For the fluorescence guided SLNB, 7.1% (1 of 14) had nonsentinel node tissue removed prior to the correct identification of the SLN, whereas gamma probe/radioactivity guided SLNB had 28.6% (4 of 14). When comparing operation time between attending and resident surgeon, time to identification of first SLN was not significantly different for fluorescence guided surgery (82 vs. 107 s, respectively) or with gamma probe (158 vs. 204 s); however, median times using the gamma probe were nearly double for both operators. We additionally show the durability of fluorescence signal up to 5 days and clear visualization of proposed tracer with commercially available intraoperative imagers.

conclusionThe use of fluorescent labeled tilmanocept decreases operative time needed for SLNB as well as reduces the amount of nonsentinel tissue removed. LEVEL OF EVIDENCE: N/A.

Indexed as

Head and Neck NeoplasmsOperative TimeSentinel Lymph Node BiopsyAnimalsFluorescenceFluorescent DyesMaleRabbitsTechnetium Tc 99m PentetateFluorescent DyesTechnetium Tc 99m Pentetateneckoral cavityradiologysentinel node biopsy

Identifiers

PMID41657334
PMCPMC13167114

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.