Evidence map›Paper›PMID 41657327›Full record

ArticleThe Journal of dermatology2026

Combination Effects of Clindamycin and Benzoyl Peroxide Against Cutibacterium acnes.

Koyo Yoshihara, Shoji Seyama, Nobukazu Hayashi, Yuki Horiuchi, Waka Ishida, Takae Yasuda, Ikue Hou, Tokihiko Shimada, Saori Murakami, Mie Kakuta and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Koyo YoshiharaDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Shoji SeyamaDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Nobukazu HayashiDepartment of Dermatology, Toranomon Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1971-230X
Yuki HoriuchiAkihabara Skin Clinic, Tokyo, Japan.
Waka IshidaWaka Skin Care Clinic, Niigata, Japan.
Takae YasudaNakano Dermatology, Hiroshima, Japan.
Ikue HouHou Dermatology Clinic, Okayama, Japan.
Tokihiko ShimadaShimada Clinic of Dermatology, Kagoshima, Japan.
Saori MurakamiMurakami Dermatology Clinic, Ehime, Japan.
Mie KakutaKakuta Clinic, Tokyo, Japan.
Junichi SugaiSugai Dermatology Park Side Clinic, Tochigi, Japan.
Masako WatanabeKobayashi Dermatology Clinic, Hyogo, Japan.
Akiko IshiiTsukuba Suzuran Dermatology Clinic, Ibaraki, Japan.
Mayumi NomotoNomotoMayumi Skincare Clinic, Niigata, Japan.
Hiroko IchimiyaIchimiya Dermatology Clinic, Oita, Japan.
Noriko TanakaMatsumoto Clinic, Fukuoka, Japan.
Chikage TakeoYoyogiuehara Dermatology Clinic, Tokyo, Japan.
Kazuha KasugaiKasugai Skin Clinic, Aichi, Japan.
Miwa KobayashiKobayashi Dermatology Clinic, Fukuoka, Japan.
Utako KimuraDepartment of Dermatology, Juntendo University School of Medicine, Chiba, Japan.
Masumi KohnoSugimoto Dermatology, Kanagawa, Japan.
Emi NakazakiEmi Skin Clinic Shoto, Tokyo, Japan.
Chiaki MuraseNagoya Garden Clinic, Aichi, Japan.ORCID https://orcid.org/0000-0001-5331-1222
Yoshitsune BanKirari Dermatology Clinic, Gifu, Japan.
Yuko FukanoMeguro Dermatology Clinic, Tokyo, Japan.
Yoshiki MiyachiGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Hidemasa NakaminamiDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Funding

JST SPRING JPMJSP2134Sun Pharma Japan
6 · The paper itself

Abstract

This study aimed to evaluate the clinical efficacy of combination therapy with clindamycin and benzoyl peroxide in treating acne vulgaris. We assessed the antimicrobial susceptibility of Cutibacterium acnes isolates obtained from these patients. In addition, the potential risk of C. acnes developing resistance to clindamycin and benzoyl peroxide following exposure was investigated in vitro. We analyzed 182 C. acnes isolates from patients with acne to evaluate the clindamycin susceptibility and resistance determinants and to examine the association between topical clindamycin use and resistance. We also tested the resistance frequency of C. acnes to clindamycin monotherapy and clindamycin/benzoyl peroxide combination therapy in vitro. The clindamycin resistance rates in the clindamycin/benzoyl peroxide and clindamycin monotherapy groups were 22.9% and 46.7%, respectively. The combination group showed a significantly lower clindamycin resistance rate (p < 0.05). Under clindamycin monotherapy, resistant strains emerged at a frequency of 8.1 × 10

Indexed as

Acne VulgarisAnti-Bacterial AgentsBenzoyl PeroxideClindamycinPropionibacterium acnesDrug CombinationsDrug Resistance, BacterialDrug Therapy, CombinationHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsBenzoyl PeroxideClindamycinDrug Combinationsantibiotic resistancebenzoyl peroxideclindamycinCutibacterium acnes

Identifiers

PMID41657327
PMCPMC12967766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.