Evidence map›Paper›PMID 41656992›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

One-Step and Universal Strategy for the Synthesis of Hypermodified Uracil Phosphoramidites acp

Ewa Mejdr, Lena Heinickel, Thomas Carell, Ivana Mejdr

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ewa MejdrDepartment of Chemistry, Institute of Chemical Epigenetics, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.ORCID https://orcid.org/0000-0001-8929-046X
Lena HeinickelDepartment of Chemistry, Institute of Chemical Epigenetics, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.
Thomas CarellDepartment of Chemistry, Institute of Chemical Epigenetics, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.ORCID https://orcid.org/0000-0001-7898-2831
Ivana MejdrDepartment of Chemistry, Institute of Chemical Epigenetics, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.ORCID https://orcid.org/0009-0007-1587-9811

Funding

BMBF in the framework of the Cluster4Future program (Cluster for Nucleic Acid Therapeutics Munich, CNATM) 03ZU1201AABundesministerium für Forschung und Technologie 03ZU1201AACollaborative Research Centers (CRC) 201269156Collaborative Research Centers (CRC) 325871075Collaborative Research Centers (CRC) 393547839Collaborative Research Centers (CRC) A4Collaborative Research Centers (CRC) A5Collaborative Research Centers (CRC) P2Deutsche Forschungsgemeinschaft CA275/11-3Deutsche Forschungsgemeinschaft CRC1032Deutsche Forschungsgemeinschaft CRC1309Deutsche Forschungsgemeinschaft CRC1361European Research Council
6 · The paper itself

Abstract

Hypermodified nucleosides have recently been at the center of scientific attention. They represent a unique group of nucleosides with an alternated structure, such as the addition of functional groups or amino acids. Their distinctive structures and positions in RNAs are crucial for the processes of translation and stability. High demand for oligonucleotides bearing those hypermodified nucleobases led us to the development of a single-step synthesis of acp

Indexed as

OligonucleotidesOrganophosphorus CompoundsUracilNucleosidesRNARNA, TransferNucleosidesOligonucleotidesOrganophosphorus CompoundsphosphoramiditeRNARNA, TransferUracilacp3Ucmnm5Uhypermodified nucleosidesoligonucleotidephosphoramidite

Identifiers

PMID41656992
PMCPMC13109688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.