Evidence map›Paper›PMID 41656983›Full record

ArticleMagnetic resonance in medicine2026

Assessment of Optimal T1/T2-Weighted Combinations for Myelin Sensitivity: Effects of Echo Time and Exponents.

Simone Monachino, Gerhard S Drenthen, Lis J M van den Boogaard, Marcel Breeuwer, Catarina Dinis Fernandes, Oliver H H Gerlach, Svitlana Zinger, Jacobus F A Jansen

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Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Simone MonachinoDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0002-1596-0667
Gerhard S DrenthenDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID 0000-0002-7708-8501
Lis J M van den BoogaardDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID 0009-0007-3327-5093
Marcel BreeuwerDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0003-1822-8970
Catarina Dinis FernandesDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0009-0000-7633-9615
Oliver H H GerlachMental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.ORCID 0009-0004-3883-5561
Svitlana ZingerDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0001-9357-3067
Jacobus F A JansenDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0002-5271-8060

Funding

Health-Holland/Hersenstichting LSHTKI PPS-BR-2023-01Philips Research
6 · The paper itself

Abstract

purposeThe aim of this study is to improve the traditional T1-weighted (T1w) over T2-weighted (T2w) ratio as a proxy for myelin by investigating the optimal T2w TE and combination of exponent-weighted T1w and T2w images (

methodsT1w and T2w Gradient And Spin Echo (GRASE) data were acquired from 14 volunteers, 6 of whom had a repeated GRASE scan.

resultsThe optimized ratio with TE

conclusionThe ratio associated with myelin can be improved using optimized parameters without compromising reliability. Specifically, low T2w TE can significantly increase the correlation with MWF. T1w over proton density-weighted (T1w/PDw) metric can be a viable alternative to

Indexed as

BrainImage Processing, Computer-AssistedMagnetic Resonance ImagingMyelin SheathAdultAlgorithmsFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleReproducibility of ResultsSensitivity and SpecificityWhite MatterGRASEmyelin sensitivitymyelin water fractionT1‐weighted/T2‐weighted ratio

Identifiers

PMID41656983
PMCPMC13049272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.