ReviewZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
[Role of hyaluronic acid synthases in female infertility-related diseases].
Review in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The hyaluronic acid synthase (HAS) family participates in key physiological processes such as follicular development, oocyte maturation, ovulation, and embryo implantation by regulating the synthesis of hyaluronic acid, and plays an important role in the female reproductive system. In recent years, studies have found that the HAS family exerts important regulatory effects in female infertility-related diseases. HAS2 plays a critical role in cumulus expansion and oocyte maturation, and abnormal expression of HAS2 may lead to impaired cumulus expansion and ovulatory disorders. HAS1 and HAS3 are associated with ovarian dysfunction and decreased endometrial receptivity. In addition, abnormal expression of the HAS family is closely related to infertility-related diseases such as polycystic ovary syndrome, endometriosis, and premature ovarian insufficiency. Systematic elucidation of the roles of the HAS family will not only help to deepen the understanding of the pathological mechanisms of female infertility-related diseases, but is also expected to provide key theoretical evidence and precise interventional targets for the development of novel diagnostic biomarkers, optimization of ovulation induction protocols, and improvement of embryo implantation success rates, ultimately promoting the individualized diagnosis and treatment of female infertility.
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