Evidence map›Paper›PMID 41656826›Full record

ArticleMuscle & nerve2026

Dynamics of Nerve Conduction Studies in Patients With Guillain-Barré Syndrome.

Samuel Arends, Laura de Koning, Judith Drenthen, Mahova Zhu, Peter Y K van den Bergh, Robert M Hadden, Nortina Shahrizaila, Ricardo C Reisin, Satoshi Kuwabara, Senda Ajroud-Driss and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Samuel ArendsDepartment of Neurology/Clinical Neurophysiology, HagaZiekenhuis, The Hague, the Netherlands.ORCID https://orcid.org/0000-0003-4279-4657
Laura de KoningDepartment of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Judith DrenthenDepartment of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Mahova ZhuDepartment of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Peter Y K van den BerghDepartment of Neurology, University Hospital St-Luc, Brussels, Belgium.
Robert M HaddenDepartment of Neurology, King's College Hospital, London, UK.ORCID https://orcid.org/0000-0002-9702-0256
Nortina ShahrizailaDepartment of Neurology, University of Malaya, Kuala Lumpur, Malaysia.
Ricardo C ReisinDepartment of Neurology, Fundacion Para la Lucha Contra Las Enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina.
Satoshi KuwabaraDepartment of Neurology, Chiba University Hospital, Chiba, Japan.ORCID https://orcid.org/0000-0002-4716-8578
Senda Ajroud-DrissDepartment of Neurology, Northwestern University Feinberg, Chicago, Illinois, USA.
Giovanni AntoniniDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University, Rome, Italy.
Claudia BalducciDepartment of Neurology, San Gerardo Hospital, Monza, Italy.
Fabio A BarrosoDepartment of Neurology, Fundacion Para la Lucha Contra Las Enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina.
Thomas H BrannaganDepartment of Neurology, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0002-1812-8331
Jan BuermannDepartment of Neurology, Saarland University Hospital, Homburg, Germany.
Carlos CasasnovasDepartment of Neurology, San Gerardo Hospital, Monza, Italy.
Guido CavalettiDepartment of Neurology, Hospital Universitario de Bellvitge Servicio de Neurologica, Barcelona, Spain.
Chi-Chao ChaoDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Ulrich DillmannDepartment of Neurology, Saarland University Hospital, Homburg, Germany.
Mazen M DimachkieDepartment of Neurology, University of Kansas Medical Center, Kansas, Missouri, USA.
Giuliana GalassiDepartment of Neurology, University Hospital of Modena, Modena, Italy.
Gerardo Gutiérrez-GutiérrezHospital Universitario Infanta Sofía, Madrid, Spain.
Thomas HarboDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Sung-Tsang HsiehDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Badrul IslamDepartment of Neurology and Neurophysiology, BRB Hospital, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0001-7129-944X
Hans KatzbergDepartment of Neurology, University of Toronto, Toronto, Canada.
Lynette KiersDepartment of Neurology, The Royal Melbourne Hospital City Campus, Melbourne, Australia.
Giorgia MataluniDysimmune Neuropathies Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Julio PardoDepartment of Neurology, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
Yann PeréonDepartment of Clinical Neurophysiology, Nantes University Hospital, Nantes, France.
Yusuf A RajaballyAston Medical School, Aston University, Birmingham, UK.ORCID https://orcid.org/0000-0002-7170-8343
Mark StettnerDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, Essen, Germany.
Camiel VerhammeDepartment of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Michal VytopilDepartment of Neurology, Lahey Hospital and Medical Center, Burlington, Vermont, USA.
Waheed WaqarDepartment of Neurology, University of Vermont Medical Centre, Burlington, Vermont, USA.
David R CornblathDepartment of Neurology, Johns Hopkins University, Baltimore, Vermont, USA.
Bart C JacobsDepartment of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
IGOS Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

aimsThe value of electrodiagnostic subtyping of Guillain-Barré syndrome (GBS) is still debated. This study aimed to determine the diagnostic yield, timing, and changes of the electrodiagnostic subtyping in patients with GBS in serial nerve conduction studies (NCS).

methodsData were extracted from the International GBS Outcome Study (IGOS) database. Serial NCS were available for 469 patients. For the serial NCS analysis, the intervals between the first and second study were defined as ≥ 7 and ≤ 42 days after onset of weakness. All NCS were classified according to the electrodiagnostic criteria sets of Hadden et al. and Rajabally et al.

resultsIn NCS conducted within 3 days of onset of weakness, an axonal or demyelinating subtype could be demonstrated in 58.4% (Hadden) and 52.1% (Rajabally). NCS performed at a later timepoint demonstrated a similar yield of axonal and demyelinating subtypes. In patients with motor-sensory and motor GBS, the electrodiagnostic subtype changed on serial NCS in 37.8% (Hadden) and 44.7% (Rajabally). As the subtypes changed in multiple and opposite directions, the total proportion of axonal and demyelinating subtypes remained stable across time points. In patients with motor GBS, both axonal and demyelinating subtypes were found. DISCUSSION: This study demonstrates the highly dynamic disease course of GBS. The role of NCS remains to support the clinical diagnosis of GBS and should be performed as quickly as possible after onset of weakness. If these early NCS are non-diagnostic, repeating the study should be considered. Electrodiagnostic subtyping offers no additional value.

Indexed as

Guillain-Barre SyndromeNerve Conduction StudiesNeural ConductionAction PotentialsAdultAgedAxonsElectrodiagnosisElectromyographyFemaleHumansMaleMiddle AgedAIDPEMGGuillain–Barré syndromenerve conduction studypolyneuropathy

Identifiers

PMID41656826
PMCPMC13047943

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.